abstract：:This work presents a study based on the preparation and characterization of drug-collagen hybrid materials. Materials used for obtaining drug-collagen hybrids were collagen type I (Coll) as matrix and fludarabine (F) and epirubicin (E) as hydrophilic active substances. After incorporation of drugs into Coll in differe...

journal_title：International journal of pharmaceutics

authors： Voicu G,Geanaliu-Nicolae RE,Pîrvan AA,Andronescu E,Iordache F

更新日期：2016-08-30 00:00:00

abstract：:In this work calcium stearate (CaSt) multi-particulates loaded with codeine phosphate (COP) were developed in an attempt to provide extended release (ER) combined with alcohol dose dumping (ADD) resistance. The pellets were prepared via wet/extrusion spheronization and ER characteristics were obtained after fluid bed ...

journal_title：International journal of pharmaceutics

authors： Schrank S,Jedinger N,Wu S,Piller M,Roblegg E

更新日期：2016-07-25 00:00:00

abstract：:The PEGylated liposomal (PEG-LP) Doxorubicin, PEG-LP (DOX), with a diameter of around 100nm, accumulates in tumors via the enhanced permeability and retention (EPR) effect, and is used clinically for the treatment of several types of cancer. However, there are a number of tumor types that are resistant to DOX. We repo...

journal_title：International journal of pharmaceutics

authors： Kibria G,Hatakeyama H,Sato Y,Harashima H

更新日期：2016-07-25 00:00:00

abstract：:In this study, the antibacterial bionanocomposites of poly(ε-caprolactone) (PCL) with different concentrations of triclosan (TC) loaded polylactic acid (PLA) nanoparticles (30wt% triclosan) (LATC30) were fabricated via a melt mixing process in order to lower the burst release of PCL and to extend the antibacterial act...

journal_title：International journal of pharmaceutics

authors： Kaffashi B,Davoodi S,Oliaei E

更新日期：2016-07-11 00:00:00

abstract：:Development of an oral docetaxel formulation has been hindered mainly due to its poor solubility and oral bioavailability. The aim of this study was to develop poloxamer F68/P85-based solid dispersions (SDs) for the oral delivery of docetaxel and investigate their in vivo pharmacokinetic impacts on the systemic absorp...

journal_title：International journal of pharmaceutics

authors： Song CK,Yoon IS,Kim DD

更新日期：2016-06-30 00:00:00

abstract：:An ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the benefits of incorporating it in a continuous line, manufacturing solid dosage forms. Tablets containing lactose, acetaminophen, and magnesium stearate ...

journal_title：International journal of pharmaceutics

authors： Razavi SM,Callegari G,Drazer G,Cuitiño AM

更新日期：2016-06-30 00:00:00

abstract：:Polyamine content, which is associated with tumor growth, can be regulated by ornithine decarboxylase (ODC) and S-adenosyl methionine decarboxylase (SAMDC), two key enzymes in polyamine biosynthesis. Here we aim to develop a pH-responsive cationic poly(agmatine) based on a polyamine analogue-agmatine that can dually f...

journal_title：International journal of pharmaceutics

authors： Cui PF,Xing L,Qiao JB,Zhang JL,He YJ,Zhang M,Lyu JY,Luo CQ,Jin L,Jiang HL

更新日期：2016-06-15 00:00:00

abstract：:Development of novel anticancer formulations is a priority challenge in biomedicine. However, in vitro models based on monolayer cultures (2D) which are currently used for cytotoxicity tests leave much to be desired. More and more attention is focusing on 3D in vitro systems which can better mimic solid tumors. The ai...

journal_title：International journal of pharmaceutics

authors： Akasov R,Zaytseva-Zotova D,Burov S,Leko M,Dontenwill M,Chiper M,Vandamme T,Markvicheva E

更新日期：2016-06-15 00:00:00

abstract：:Hydrotalcite (HT), also known as a layered double hydroxide (LDH) compound, has been widely used in past years in the formulation of drugs due to its specific properties including good biocompatibility, null toxicity, high chemical stability and pH-dependent solubility which aid in drug controlled release. In this wor...

journal_title：International journal of pharmaceutics

authors： Djebbi MA,Bouaziz Z,Elabed A,Sadiki M,Elabed S,Namour P,Jaffrezic-Renault N,Amara AB

更新日期：2016-06-15 00:00:00

abstract：:In this proof-of-concept study, a methodology is proposed to systematically analyze large data historians of secondary pharmaceutical manufacturing systems using data mining techniques. The objective is to develop an approach enabling to automatically retrieve operation-relevant information that can assist the managem...

journal_title：International journal of pharmaceutics

authors： Meneghetti N,Facco P,Bezzo F,Himawan C,Zomer S,Barolo M

更新日期：2016-05-30 00:00:00

abstract：:Supercritical fluid assisted atomization introduced by a hydrodynamic cavitation mixer (SAA-HCM) was proposed as a green technique to fabricate insulin-loaded dry powders for inhalation administration. N-trimethyl chitosan (TMC), a polymeric mucoadhesive absorption enhancer, was synthesized and successfully micronized...

journal_title：International journal of pharmaceutics

authors： Shen YB,Du Z,Tang C,Guan YX,Yao SJ

更新日期：2016-05-30 00:00:00

abstract：:RNA interfere (RNAi)-based technology holds great promise in cancer treatment. The use of small interfering RNA (siRNA), however, is hampered by its low delivery efficiency in vivo when they are diluted in blood biofluids and in the presence of serum and salt. In this study, we developed the polyglutamate derivative p...

journal_title：International journal of pharmaceutics

authors： Wang Z,Zou H,Wang Z,Wu J,Xia Z,Feng M

更新日期：2016-05-30 00:00:00

abstract：:Bisphenol A (BPA) is an endocrine disruptor found in food containers and plastic beverages and also in medical devices such as dialyzers. The aim of this study is while taking into account the BPA originating in medical devices and the water used in dialysate production, to provide the first published investigation of...

journal_title：International journal of pharmaceutics

authors： Bacle A,Thevenot S,Grignon C,Belmouaz M,Bauwens M,Teychene B,Venisse N,Migeot V,Dupuis A

更新日期：2016-05-30 00:00:00

abstract：:For effective topical delivery, a drug must cross the stratum corneum (SC) barrier into viable tissue. The use of permeation enhancers is a widespread approach for barrier modification. In the current study, flufenamic acid (FluA), a non-steroidal anti-inflammatory drug, is a model agent for investigating the influenc...

journal_title：International journal of pharmaceutics

authors： Pyatski Y,Zhang Q,Mendelsohn R,Flach CR

更新日期：2016-05-30 00:00:00

abstract：:A reproducible double emulsion/solvent evaporation procedure is developed to formulate magnetic solid lipid nanoparticles (average size≈180 nm) made of iron oxide cores embedded within a glyceryl trimyristate solid matrix. The physicochemical characterization of the nanocomposites ascertained the efficacy of the prepa...

journal_title：International journal of pharmaceutics

authors： Muñoz de Escalona M,Sáez-Fernández E,Prados JC,Melguizo C,Arias JL

更新日期：2016-05-17 00:00:00

abstract：:This work investigates the dispersion performance of fine lactose particles as function of processing time, and compares it to the API, using Beclomethasone Dipropionate (BDP) as model API. The total load of fine particles is kept constant in the formulations while the proportions of API and lactose fines are varied. ...

journal_title：International journal of pharmaceutics

authors： Thalberg K,Åslund S,Skogevall M,Andersson P

更新日期：2016-05-17 00:00:00

abstract：:Pharmaceutical powders are typically insulators consisting of relatively small particles and thus they usually exhibit significant electrostatic charging behaviours. In the inhalation field, the measurement of electrostatic charge is an imperative stage during pharmaceutical formulation development. The electrostatic ...

journal_title：International journal of pharmaceutics

authors： Kaialy W

更新日期：2016-04-30 00:00:00

abstract：:Cyclosporine A (CsA) is a well-known immunosuppressive agent used as rescue therapy in severe steroid-refractory ulcerative colitis (UC). However, toxicity issues associated with CsA when administered in its commercially available formulations have been reported in clinical practice. Since nanotechnology has been prop...

journal_title：International journal of pharmaceutics

authors： Guada M,Beloqui A,Alhouayek M,Muccioli GG,Dios-Viéitez Mdel C,Préat V,Blanco-Prieto MJ

更新日期：2016-04-30 00:00:00

abstract：:The aim of this work was to evaluate the suitability of stereolithography (SLA) to fabricate drug-loaded tablets with modified-release characteristics. The SLA printer creates solid objects by using a laser beam to photopolymerise monomers. In this work polyethylene glycol diacrylate (PEGDA) was used as a monomer and ...

journal_title：International journal of pharmaceutics

authors： Wang J,Goyanes A,Gaisford S,Basit AW

更新日期：2016-04-30 00:00:00

abstract：:Periplogenin (PPG), a cardiac glycoside prepared from Cortex periplocae, with similar structure to bufalin, has been found to induce apoptosis in many tumor cells. However, lots of cardiac glycosides possessing strong antitumor activity in vitro have still not passed phase I clinical trials, mostly due to poor tumor s...

journal_title：International journal of pharmaceutics

authors： Zhang HY,Xu WQ,Wang YW,Omari-Siaw E,Wang Y,Zheng YY,Cao X,Tong SS,Yu JN,Xu XM

更新日期：2016-04-11 00:00:00

abstract：:Virus-like particles (VLPs) have been exploited for various biomedical applications, such as the monitoring, prevention, diagnosis and therapy of disease. In this study, a novel multifunctional VLPs nanocarrier (TK-VLPs) was prepared and used for tumor-targeted delivery. The SPR and cell uptake results indicated that ...

journal_title：International journal of pharmaceutics

authors： Ren Y,Mu Y,Jiang L,Yu H,Yang S,Zhang Y,Wang J,Zhang H,Sun H,Xiao C,Peng H,Zhou Y,Lu W

更新日期：2016-04-11 00:00:00

abstract：:A series of cell-penetrating PepFect peptide analogues was developed by substitutions of the galanin-derived N-terminal sequence. Histidine modifications were incorporated in order to make the peptides pH-responsive. The peptides were all able to form non-covalent complexes with an oligonucleotide cargo by co-incubati...

journal_title：International journal of pharmaceutics

authors： Regberg J,Vasconcelos L,Madani F,Langel Ü,Hällbrink M

更新日期：2016-03-30 00:00:00

abstract：:Epirubicin (EPI) is a P-gp substrate antracycline analogue which elicits poor oral bioavailability. In the present work, EPI loaded poly-lactide-co-glycolic acid nanoparticles (PLGA-NPs) were prepared by double emulsion approach and superficially decorated with polyethylene glycol (EPI-PNPs) and mannosamine (EPI-MNPs)...

journal_title：International journal of pharmaceutics

authors： Tariq M,Alam MA,Singh AT,Panda AK,Talegaonkar S

更新日期：2016-03-30 00:00:00

abstract：:Owing to their unique and interesting properties, extensive research round the globe has been carried out on carbon nanotubes and carbon nanotubes based systems to investigate their practical usefulness in biomedical applications. The results from these studies demonstrate a great promise in their use in targeted drug...

journal_title：International journal of pharmaceutics

authors： Sajid MI,Jamshaid U,Jamshaid T,Zafar N,Fessi H,Elaissari A

更新日期：2016-03-30 00:00:00

abstract：:The dual-ligand dendritic polyamidoamine-(polyethylene glycol)n-cyclic RGDyC peptide-(TAT peptide) (PPnR(T)) with various supplied molar ratios of polyethylene glycol (PEG) to polyamidoamine (PAMAM) (n=5, 15, 30) were designed as drug-carriers for the treatment of neovascular diseases; their targeting and penetrating ...

journal_title：International journal of pharmaceutics

authors： Li J,Zhang X,Wang M,Li X,Mu H,Wang A,Liu W,Li Y,Wu Z,Sun K

更新日期：2016-03-30 00:00:00

abstract：AIM:Assessment of preactivated carboxymethyl cellulose as potential excipient for buccal drug delivery. METHODS:Firstly, carboxymethyl cellulose (CMC) and cysteine (SH) were covalently coupled via amide bond formation to obtain thiolated carboxymethyl cellulose (CMC-SH). Further, preactivated carboxymethyl cellulose (...

journal_title：International journal of pharmaceutics

authors： Laffleur F,Bacher L,Vanicek S,Menzel C,Muhammad I

更新日期：2016-03-16 00:00:00

abstract：:Micellization offers several advantages for the delivery of water insoluble drugs including a nanoparticulate 'core-shell' delivery system for drug targeting. Recently, hydrophobically modified polysaccharides (HMPs) are gaining recognition as micelle forming polymers to encapsulate hydrophobic drugs. In this manuscri...

journal_title：International journal of pharmaceutics

authors： Muley P,Kumar S,El Kourati F,Kesharwani SS,Tummala H

更新日期：2016-03-16 00:00:00

abstract：:The relationships between data of passage through Caco-2 cultured cell lines (log Papp), taken from the literature, for 38 structurally unrelated compounds and both n-octanol lipophilicity parameters (log P(N) and log D(7.4)) and phospholipid affinity indexes were investigated. Phospholipid affinity(log k W(IAM)) was ...

journal_title：International journal of pharmaceutics

authors： Grumetto L,Russo G,Barbato F

更新日期：2016-03-16 00:00:00

abstract：:The aim of this in vivo study was to assess the ability of the prodrug conjugate diclofenac-β-cyclodextrin to release diclofenac in the colon following oral administration, using sulfapyridine (a metabolite of sulfasalazine) as a marker of colonic absorption. Two groups of rats were used; the test rats received a susp...

journal_title：International journal of pharmaceutics

authors： Vieira AC,Serra AC,Veiga FJ,Gonsalves AM,Basit AW,Murdan S

更新日期：2016-03-16 00:00:00

abstract：:Three-dimensional printing includes a wide variety of manufacturing techniques, which are all based on digitally-controlled depositing of materials (layer-by-layer) to create freeform geometries. Therefore, three-dimensional printing processes are commonly associated with freeform fabrication techniques. For years, th...

journal_title：International journal of pharmaceutics

authors： Goole J,Amighi K

更新日期：2016-02-29 00:00:00

abstract：:Solid lipid nanoparticles (SLNs) conjugated with tamoxifen (TX) and lactoferrin (Lf) were applied to carry anticancer carmustine (BCNU) across the blood-brain barrier (BBB) for enhanced antiproliferation against glioblastoma multiforme (GBM). BCNU-loaded SLNs with modified TX and Lf (TX-Lf-BCNU-SLNs) were used to pene...

journal_title：International journal of pharmaceutics

authors： Kuo YC,Cheng SJ

更新日期：2016-02-29 00:00:00

abstract：:The aim of this study was to design a controlled release vehicle for insulin to preserve its stability and biological activity during fabrication and release. A modified, double emulsion, solvent evaporation, technique using homogenisation force optimised entrapment efficiency of insulin into biodegradable nanoparticl...

journal_title：International journal of pharmaceutics

authors： Haggag Y,Abdel-Wahab Y,Ojo O,Osman M,El-Gizawy S,El-Tanani M,Faheem A,McCarron P

更新日期：2016-02-29 00:00:00

abstract：:The combination of essential oils (EOs) with antibiotics provides a promising strategy towards combating resistant bacteria. We have selected a mixture of 3 major components extracted from EOs: carvacrol (oregano oil), eugenol (clove oil) and cinnamaldehyde (cinnamon oil). These compounds were successfully encapsulate...

journal_title：International journal of pharmaceutics

authors： Valcourt C,Saulnier P,Umerska A,Zanelli MP,Montagu A,Rossines E,Joly-Guillou ML

更新日期：2016-02-10 00:00:00

abstract：:Amorphous nanoparticles are able to enhance the kinetic solubility and concomitant dissolution rates of BCS class II and BCS class II/IV molecules due to their characteristic increased supersaturation levels, smaller particle size and greater surface area. A DoE approach was applied to investigate formulation and spra...

journal_title：International journal of pharmaceutics

authors： Jog R,Kumar S,Shen J,Jugade N,Tan DC,Gokhale R,Burgess DJ

更新日期：2016-02-10 00:00:00

abstract：:Administration of drugs via the oral route is the most common and preferred route due to its ease of administration, cost-effectiveness and flexibility in design. However, if the drug being administered has limited aqueous solubility it can result in poor bioavailability. Furthermore, the low pH of the stomach as well...

journal_title：International journal of pharmaceutics

authors： Shergill M,Patel M,Khan S,Bashir A,McConville C

更新日期：2016-01-30 00:00:00

abstract：:To develop a novel sodium fusidate-loaded triple polymer hydrogel dressing (TPHD), numerious polyvinyl alcohol-based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method, and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, sodium...

journal_title：International journal of pharmaceutics

authors： Jin SG,Kim KS,Kim DW,Kim DS,Seo YG,Go TG,Youn YS,Kim JO,Yong CS,Choi HG

更新日期：2016-01-30 00:00:00

abstract：:Self-nanoemulsifying formulations (SNEFs) structured with PEG 4000 as PEGylated SNEFs, were formulated after solubility studies using rational blends of soybean oil, a combination of Kolliphor(®) EL and Kolliphor(®) P188 as surfactants, and Transcutol(®) HP as co-surfactant, and evaluated for oral delivery of gentamic...

journal_title：International journal of pharmaceutics

authors： Umeyor C,Attama A,Uronnachi E,Kenechukwu F,Nwakile C,Nzekwe I,Okoye E,Esimone C

更新日期：2016-01-30 00:00:00

abstract：:Some lipophilic fluoro-substituted N-benzoyl-2-aminobenzothiazole antibacterial agents have been evaluated for their activity in the presence of cyclodextrins (CDs) containing aqueous solutions where CDs are adopted as solubilizing excipients for improving the poor water solubility of these compounds. For such purpose...

journal_title：International journal of pharmaceutics

authors： Trapani A,De Laurentis N,Armenise D,Carrieri A,Defrenza I,Rosato A,Mandracchia D,Tripodo G,Salomone A,Capriati V,Franchini C,Corbo F

更新日期：2016-01-30 00:00:00

abstract：:A green and mild approach for the preparation of reduced graphene oxide (rGO) was proposed by using riboflavin-5'-phosphate sodium salt dihydrate as a reducing reagent and stabilizer without any other reagent. The fabricated nano-rGO was systematically evaluated for its application as nano-carrier for pH-sensitive dru...

journal_title：International journal of pharmaceutics

authors： Ma N,Zhang B,Liu J,Zhang P,Li Z,Luan Y

更新日期：2015-12-30 00:00:00

abstract：:The tack of a pressure sensitive adhesive (PSA) is not an inherent material property and strongly depends on the measurement conditions. Following the concept of a measurement system analysis (MSA), influencing factors of the probe tack test were investigated by a design of experiments (DoE) approach. A response surfa...

journal_title：International journal of pharmaceutics

authors： Michaelis M,Leopold CS

更新日期：2015-12-30 00:00:00